HistoCore & IHC Lab
The HistoCore and IHC Lab is a core facility of the Center for Translational Pathology, administered by the Department of Pathology and Laboratory Medicine at NewYork-Presbyterian/Weill Cornell Medical Center. We support WCM and external investigators with high-quality morphologic workflows and project consultation to accelerate translational research.
- Access to archival and frozen tissue resources within Pathology
- Broad menu: processing → staining → imaging → quantification
- Project tracking, research integrity monitoring, publication support
Core capabilities
Tissue processing, sectioning, routine and special stains, IHC, and in situ hybridization—built for quality and reproducibility.
Brightfield whole-slide scanning and quantitative analysis workflows to support publication-ready outputs.
Consultation for tissue handling and experimental design, plus statistical support for analysis and manuscript preparation.
Submitted projects are logged and tracked in a database to support throughput, monitor research integrity, and enable reporting of publications resulting from these investigations.
Services
Fee schedules and service details are available upon request.
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1Email CTP intake with tissue type, endpoints, and timing
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2Align on workflow, QC, and deliverables (slides, images, quant outputs)
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3Submit samples with required metadata
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4Receive outputs + optional analysis support for figures/publications
Instrumentation & platforms
- Modular tissue processing for histologic specimens
- Supports standardized fixation and paraffin infiltration workflows
- Designed for reproducible processing across batches
- Runs multiple IHC protocols simultaneously
- Optional deparaffinization and pretreatment
- Customizable protocols and chromogen options
- Supports double and triple staining for co-expression studies
- Polymer-HRP (DAB) with hematoxylin counterstain commonly used
- Construct slides containing hundreds of individual tissues
- Improves throughput, standardization, and tissue conservation
- Compatible with histochemical and molecular detection techniques
- Scan up to ~400 slides per load (configuration dependent)
- Convert glass slides to digital files stored in a managed database
- Research and biopharma workflows supported
- Workstation access for independent analysis by request
- Automated visualization and quantification of biomarkers
- Modules support cytonuclear IHC, membrane IHC, ISH, and more
- Publication-ready outputs and standardized reporting
For multiplex and spatial platforms (e.g., Vectra Polaris/CODEX, GeoMx DSP), see the MISI / Multiplex Lab page.
Resources
Faculty leadership
Contact & intake
Not sure which stain or workflow fits your study? Start with a brief intake email and we'll recommend the most efficient path.
Email intake